Prescription Estriol Facial Cream

Compounded estriol cream for menopausal skin changes.

Custom-compounded estriol 0.3% with vitamin C 1% and hyaluronic acid 0.5% in a 30g pump. Supports skin hydration, texture, and tone as estrogen levels decline.

Low Cost
$125
total, first fill
no subscription
Quick
1–2
business days
clinician review
Easy
0
appointments
online intake
How It Works
$50 service fee · ~$75 compounding pharmacy · 30g lasts 2–4 months · 16 states

The Difference

Pay once. Fill when you need to. No subscription.

$50 consult + ~$75 pharmacy = ~$125 one-time. A 30g pump typically lasts 2–4 months. Reorder on your schedule, not an auto-refill calendar.

For Comparison

Typical online services for compounded estriol skincare charge $33–$50 per month on auto-refill, adding up to $400–$600 per year even if you don't need that much cream.

Range reflects common direct-to-consumer pricing for comparable services as of 2026.

What It Does

Menopausal skin needs more than moisturizer.

As estrogen declines, the skin loses collagen, hydration, and elasticity faster than general moisturizers can replace. Topical estriol supports skin thickness and elasticity during and after menopause. Combined with vitamin C (antioxidant brightening) and hyaluronic acid (deep hydration), this custom-compounded cream supports healthy, resilient skin.

Thin, Crepey Skin. Estrogen loss accelerates collagen breakdown. Estriol supports dermal thickness and elasticity.

Persistent Dryness. Aging skin retains less moisture. Hyaluronic acid (up to 1,000× its weight in water) restores hydration.

Uneven Tone. Vitamin C brightens, evens tone, and protects against environmental damage.

Overall Quality. Many patients report firmer, smoother skin within 8–12 weeks of consistent nightly use.

Active Ingredients

Three evidence-based actives.

01
🌿

Estriol 0.3%

The weakest naturally occurring estrogen, with primarily local action. Supports skin thickness and elasticity as estrogen levels decline.

02
🍊

Vitamin C 1%

Antioxidant that brightens skin tone and offers environmental protection against free radical damage.

03
💧

Hyaluronic Acid 0.5%

Humectant that draws water into the skin, restoring hydration and improving surface plumpness.

04
📏

30g Pump with Refill

30 grams with one refill included. Typical use: 1 pump nightly lasts ~4 months, 2 pumps nightly lasts ~2 months.

~$75 compounding pharmacy cost
How to Get Your Prescription

Async intake. Clinician review.

1

Online Intake

Secure questionnaire covering medical and skin history. 5–10 minutes.

2

Clinician Review

Licensed clinician reviews your request. Typically 1–2 business days.

3

Prescription Sent

Sent to the compounding pharmacy. You pay the pharmacy directly (~$75) separately from our $50 service fee.

About Custom-Compounded Estriol Cream

This cream is custom-compounded by a licensed compounding pharmacy based on individual prescriptions. Compounded medications are not FDA-approved as commercial products. Estriol is a prescription ingredient; we evaluate each request individually.

We do not prescribe to patients with active or recent estrogen-sensitive cancers, during pregnancy or breastfeeding, or in patients under 18. Please disclose your medical history fully during intake.

Other Online Prescriptions

Explore other products

Important Safety Information

Before starting estriol facial cream, please read.

See our full prescribing and safety terms, including the off-label prescribing disclosure and compounded-medications disclosure.

Common Questions

Estriol facial cream, answered.

$50 service fee + approximately $75 from the compounding pharmacy. One 30g pump typically lasts 2–4 months depending on use. Not covered by insurance (compounded).
Hydration improvements typically appear within 2–3 weeks. Skin texture and firmness changes develop over 8–12 weeks of consistent nightly use.
Apply 1 pump (or 2 if you prefer more coverage) to clean, dry skin nightly after cleansing. Avoid the eye area. Pairs well with a daily morning sunscreen.
Yes, many patients use tretinoin + estriol facial cream together. We typically recommend alternating nights at first, then combining as tolerance builds.
No. This is a custom-compounded medication prepared by a licensed pharmacy based on individual prescription. Compounded medications are not FDA-approved commercial products.
We do not prescribe to patients with active or recent estrogen-sensitive cancers through this async service. Please discuss topical estriol options with your oncologist first.

Ready to support
your menopausal skin?

$50 service fee. Custom-compounded estriol + vitamin C + hyaluronic acid. Available in 16 states.

131 N Washington Street, Suite A · Papillion, NE 68046 · Info@midwestmindandbodyhealthcare.com

Please do not send protected health information (PHI) by email. For secure communication about your care, use our patient portal after booking.

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